The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.

The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.

Brain-derived neurotrophic factor (BDNF) importantly regulates learning and memory and supports the survival of injured neurons. Reduced BDNF levels have been detected in the brains of Alzheimer's disease (AD) patients but the exact role of BDNF in the pathophysiology of the disorder remains ob...

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Bibliographic Details
Main Authors: Tomi Rantamäki, Susanna Kemppainen, Henri Autio, Saara Stavén, Hennariikka Koivisto, Masami Kojima, Hanna Antila, Pasi O Miettinen, Elisa Kärkkäinen, Nina Karpova, Liisa Vesa, Lothar Lindemann, Marius C Hoener, Heikki Tanila, Eero Castrén
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3700921?pdf=render

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http://europepmc.org/articles/PMC3700921?pdf=render

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