Development and validation of a UPLC–MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics

Development and validation of a UPLC–MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics

A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative (2'-deoxy-2', 2'-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and validated. The conventional plasm...

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Bibliographic Details
Main Authors: Gang Wang, Dongyang Zhao, Hongxiang Chen, Dawei Ding, Longfa Kou, Lifang Sun, Chenxia Hao, Xincong Li, Kai Jia, Qiming Kan, Xiaohong Liu, Zhonggui He, Jin Sun
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Gemcitabine
L-carnitine
Prodrug
Pharmacokinetics
UPLC/MS/MS
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616301040

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http://www.sciencedirect.com/science/article/pii/S1818087616301040

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