5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells

5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells

Despite high cure rates, about 20% of patients with advanced germ cell tumors (GCTs) fail cisplatin-based chemotherapy. High levels of DNA methylation have been identified in GCTs and linked to cisplatin resistance. Here, we examined the effects of DNA hypomethylating 5-azacitidine (5-aza) on two em...

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Bibliographic Details
Main Authors: Christoph Oing, Izudin Verem, Wael Y. Mansour, Carsten Bokemeyer, Sergey Dyshlovoy, Friedemann Honecker
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
germ cell tumor
5-azacitidine
DNA demethylation
DNA methyl transferase (DNMT) inhibition
cisplatin resistance
Online Access:https://www.mdpi.com/1422-0067/20/1/21

Internet

https://www.mdpi.com/1422-0067/20/1/21

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