Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase

Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase

Mice lacking phosphatidylethanolamine N-methyltransferase (PEMT) are protected from high-fat diet (HFD)-induced obesity and insulin resistance. However, these mice develop severe nonalcoholic fatty liver disease (NAFLD) when fed the HFD, which is mainly due to inadequate secretion of VLDL particles....

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Bibliographic Details
Main Authors: Jelske N. van der Veen, Susanne Lingrell, Xia Gao, Abhijit Takawale, Zamaneh Kassiri, Dennis E. Vance, René L. Jacobs
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Journal of Lipid Research
Subjects:
nonalcoholic fatty liver disease
phosphatidylcholine
peroxisome proliferator-activated receptor-α
fibric acids
steatohepatitis
liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752033844X

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http://www.sciencedirect.com/science/article/pii/S002222752033844X

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