Alternative splicing of coq-2 controls the levels of rhodoquinone in animals

Alternative splicing of coq-2 controls the levels of rhodoquinone in animals

Parasitic helminths use two benzoquinones as electron carriers in the electron transport chain. In normoxia, they use ubiquinone (UQ), but in anaerobic conditions inside the host, they require rhodoquinone (RQ) and greatly increase RQ levels. We previously showed the switch from UQ to RQ synthesis i...

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Bibliographic Details
Main Authors: June H Tan, Margot Lautens, Laura Romanelli-Cedrez, Jianbin Wang, Michael R Schertzberg, Samantha R Reinl, Richard E Davis, Jennifer N Shepherd, Andrew G Fraser, Gustavo Salinas
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
rhodoquinone
parasitic helminth
anaerobic metabolism
alternative splicing
annelid
mollusc
Online Access:https://elifesciences.org/articles/56376

Internet

https://elifesciences.org/articles/56376

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