A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration

A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration

Abstract Background The senescence of nucleus pulposus (NP) cells plays a vital role in the pathogenesis of intervertebral disc (IVD) degeneration (IDD). NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce premature NP cell senescence. Enhancer of zeste homolog 2 (EZH2) is a...

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Bibliographic Details
Main Authors: Chang Liu, Libangxi Liu, Minghui Yang, Bin Li, Jiarong Yi, Xuezheng Ai, Yang Zhang, Bo Huang, Changqing Li, Chencheng Feng, Yue Zhou
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Cell Division
Subjects:
Intervertebral disc degeneration
Nucleus pulposus cell senescence
Epigenetic histone modification
Wnt/β-catenin signaling pathway
Online Access:https://doi.org/10.1186/s13008-020-0060-x

Internet

https://doi.org/10.1186/s13008-020-0060-x

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