TGF-b downregulation by RNAi technique in ex vivo-expanded HSCs on 3D DBM scaffold

Background: Bone Marrow Transplantations (BMT) are limited by low CD34+ cell counts in umbilical cord blood (UCB) and these cells need to be expanded for success in such procedures. To achieve this goal, ex vivo expansion of hematopoietic stem cells (HSCs) by enhancing their self-renewal activity on...

Full description

Bibliographic Details
Main Authors: Hashemi ZS, Forouzandeh Moghadam M, Soleimani M, Hafizi M, Amirizadeh N
Format: Article
Language:fas
Published: Tehran University of Medical Sciences 2012-05-01
Series:Tehran University Medical Journal
Subjects:
Online Access:http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-142&slc_lang=en&sid=1