The Value of a Rapid Test of Human Regulatory T Cell Function Needs to be Revised

The Value of a Rapid Test of Human Regulatory T Cell Function Needs to be Revised

CD4+CD25+FoxP3+ human regulatory TCELLS (TREG) are promising candidates for reshaping undesired immunity/inflammation by adoptive cell transfer, yet their application is strongly dependent on robust assays testing their functionality. Several studies along with first clinical data indicate TREG to b...

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Bibliographic Details
Main Authors: Desiree J. Wendering, Leila Amini, Stephan Schlickeiser, Petra Reinke, Hans-Dieter Volk, Michael Schmueck-Henneresse
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
regulatory T cell functional assay
αCD3/28-coated microbeads
competitive CD3/CD28 binding
nullified Treg-mediated suppression
correlation between T cell-to-αCD3/CD28-coated microbead ratio and activation marker frequency on responder T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00150/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00150/full

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