A High-Content Screening Approach to Identify MicroRNAs Against Head and Neck Cancer Cell Survival and EMT in an Inflammatory Microenvironment

A High-Content Screening Approach to Identify MicroRNAs Against Head and Neck Cancer Cell Survival and EMT in an Inflammatory Microenvironment

Head and neck squamous cell carcinoma (HNSCC) is among the most common cancer types. Metastasis, the main cause of death by cancer, can be promoted by an inflammatory microenvironment, which induces epithelial-mesenchymal transition (EMT) through a NF-κB-mediated stabilization of Snail. Here, we aim...

Full description

Bibliographic Details
Main Authors: Bruno Sangiorgi, Felipe Canto de Souza, Ildercílio Mota de Souza Lima, Josiane Lilian dos Santos Schiavinato, Amanda Cristina Corveloni, Carolina Hassibe Thomé, Wilson Araújo Silva, Vitor Marcel Faça, Dimas Tadeu Covas, Marco Antônio Zago, Rodrigo Alexandre Panepucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
head and neck squamous cell carcinoma
high-content screening
microRNAs
epithelial-mesenchymal-transition
inflammation
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01100/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01100/full

Similar Items