Tripartite motif-containing 3 (TRIM3) enhances ER signaling and confers tamoxifen resistance in breast cancer

Tripartite motif-containing 3 (TRIM3) enhances ER signaling and confers tamoxifen resistance in breast cancer

Abstract Tamoxifen resistance remains a clinical problem in estrogen receptor (ER)-positive breast cancer. SUMOylation of ERα enhances ERα-induced transcription activity. Tripartite motif-containing (TRIM) proteins are a new class of SUMO E3 ligases, which regulate the SUMOylation of proteins. Howev...

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Bibliographic Details
Main Authors: Runyi Ye, NiJiati AiErken, Xiaying Kuang, Huijuan Zeng, Nan Shao, Ying Lin, Pian Liu, Shenming Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-021-00350-x

Internet

https://doi.org/10.1038/s41389-021-00350-x

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