Apoptosis induction and AKT/NF-κB inactivation are associated with regroafenib-inhibited tumor progression in non-small cell lung cancer in vitro and in vivo

Apoptosis induction and AKT/NF-κB inactivation are associated with regroafenib-inhibited tumor progression in non-small cell lung cancer in vitro and in vivo

Non-small cell lung cancer (NSCLC) is a malignant lung cancer type with poor prognosis. NF-κB, the oncogenic transcription factor, has been recognized as an important mediator in progression of NSCLC. Regorafenib, a multikinase inhibitor, was demonstrated to inhibit tumor progression through suppres...

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Bibliographic Details
Main Authors: Mao-Chi Weng, Ming-Hsin Li, Jing Gung Chung, Yu-Chang Liu, Jeng-Yuan Wu, Fei-Ting Hsu, Hsin-Ell Wang
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Non-small cell lung cancer
Regorafenib
AKT
NF-κB
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219317512

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http://www.sciencedirect.com/science/article/pii/S0753332219317512

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