Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content.

Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content.

One serious side effect of statin drugs is skeletal muscle myopathy. Although the mechanism(s) responsible for statin myopathy remains to be fully determined, an increase in muscle atrophy gene expression and changes in mitochondrial content and/or function have been proposed to play a role. In this...

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Bibliographic Details
Main Authors: Craig A Goodman, Derk Pol, Evelyn Zacharewicz, Robert S Lee-Young, Rod J Snow, Aaron P Russell, Glenn K McConell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4447258?pdf=render

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http://europepmc.org/articles/PMC4447258?pdf=render

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