Hydrophobic Tagging-Mediated Degradation of Transcription Coactivator SRC-1

Hydrophobic Tagging-Mediated Degradation of Transcription Coactivator SRC-1

Steroid receptor coactivator-1 (SRC-1) is a transcription coactivator playing a pivotal role in mediating a wide range of signaling pathways by interacting with related transcription factors and nuclear receptors. Aberrantly elevated SRC-1 activity is associated with cancer metastasis and progressio...

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Bibliographic Details
Main Authors: So Ra Choi, Hee Myeong Wang, Min Hyeon Shin, Hyun-Suk Lim
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
PROTACs
hydrophobic tagging
ubiquitin–proteasome system
ubiquitination
proteasomal degradation
cancer metastasis
Online Access:https://www.mdpi.com/1422-0067/22/12/6407

Internet

https://www.mdpi.com/1422-0067/22/12/6407

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