A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture after Exposure to Cigarette Smoke in Vitro

To establish a relevant in vitro model for systems toxicology-based mechanistic assessment of environmental stressors such as cigarette smoke (CS), we exposed human organotypic bronchial epithelial tissue cultures at the air liquid interface (ALI) to various CS doses. Previously, we compared in vitr...

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Bibliographic Details
Main Authors: Carole Mathis, Stephan Gebel, Carine Poussin, Vincenzo Belcastro, Alain Sewer, Dirk Weisensee, Arnd Hengstermann, Sam Ansari, Sandra Wagner, Manuel C. Peitsch, Julia Hoeng
Format: Article
Language:English
Published: SAGE Publishing 2015-01-01
Series:Bioinformatics and Biology Insights
Online Access:https://doi.org/10.4137/BBI.S19908