Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle

Summary: The necessity of mesenchymal stromal cells, called fibroadipogenic progenitors (FAPs), in skeletal muscle regeneration and maintenance remains unestablished. We report the generation of a PDGFRαCreER knockin mouse model that provides a specific means of labeling and targeting FAPs. Depletio...

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Bibliographic Details
Main Authors: Michael N. Wosczyna, Colin T. Konishi, Edgar E. Perez Carbajal, Theodore T. Wang, Rachel A. Walsh, Qiang Gan, Mark W. Wagner, Thomas A. Rando
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719305546