Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells

Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells

High glucose and fatty acid levels impair pancreatic beta cell function. We have recently shown that palmitate-induced loss of INS-1E insulinoma cells is related to increased reactive oxygen species (ROS) production as both toxic effects are prevented by palmitoleate. Here we show that palmitate-in...

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Bibliographic Details
Main Authors: Jonathan Barlow, Verena Hirschberg Jensen, Charles Affourtit
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Redox Biology
Subjects:
Pancreatic beta cells
Glucolipotoxicity
Cytoprotection
Mitochondrial dysfunction
Uncoupling protein-2 (UCP2)
Reactive oxygen species
INS-1E insulinoma cells
Non-esterified fatty acids
Obesity
Type 2 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714001219

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http://www.sciencedirect.com/science/article/pii/S2213231714001219

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