Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition[S]

Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition[S]

Plasma apoC-III levels correlate with triglyceride (TG) levels and are a strong predictor of CVD outcomes. ApoC-III elevates TG in part by inhibiting LPL. ApoC-III likely inhibits LPL by competing for lipid binding. To probe this, we used oil-drop tensiometry to characterize binding of six apoC-III...

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Bibliographic Details
Main Authors: Nathan L. Meyers, Mikael Larsson, Evelina Vorrsjö, Gunilla Olivecrona, Donald M. Small
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Journal of Lipid Research
Subjects:
lipoprotein lipase
lipid and lipoprotein metabolism
LDL/metabolism
lipid/emulsions
protein-lipid interaction
surface pressure
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520338207

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http://www.sciencedirect.com/science/article/pii/S0022227520338207

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