A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five

A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five

Hereditary spastic paraplegia is a spastic gait disorder that arises from degeneration of corticospinal axons. The subtype SPG48 is associated with mutations in the zeta subunit of the adaptor protein complex five (AP5). AP5 function and the pathophysiology of SPG48 are only poorly understood. Here,...

Full description

Bibliographic Details
Main Authors: Mukhran Khundadze, Federico Ribaudo, Adeela Hussain, Jan Rosentreter, Sandor Nietzsche, Melanie Thelen, Dominic Winter, Birgit Hoffmann, Muhammad Awais Afzal, Tanja Hermann, Cecilia de Heus, Eva-Maria Piskor, Christian Kosan, Patricia Franzka, Lisa von Kleist, Tobias Stauber, Judith Klumperman, Markus Damme, Tassula Proikas-Cezanne, Christian A. Hübner
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
AP5
ALR
Autophagy
Lysosome
SPG48
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300798

Internet

http://www.sciencedirect.com/science/article/pii/S0969996119300798

Similar Items