Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive Classes

Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive Classes

Summary: It has been posited that anti-tumoral innate activation is driven by derepression of endogenous repeats. We compared RNA sequencing protocols to assess repeat transcriptomes in The Cancer Genome Atlas (TCGA). Although poly(A) selection efficiently detects coding genes, most non-coding genes...

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Bibliographic Details
Main Authors: Alexander Solovyov, Nicolas Vabret, Kshitij S. Arora, Alexandra Snyder, Samuel A. Funt, Dean F. Bajorin, Jonathan E. Rosenberg, Nina Bhardwaj, David T. Ting, Benjamin D. Greenbaum
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471830384X

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http://www.sciencedirect.com/science/article/pii/S221112471830384X

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