Neuroprotective Effect of Optogenetics Varies With Distance From Channelrhodopsin-2 Expression in an Amyloid-β-Injected Mouse Model of Alzheimer’s Disease

Neuroprotective Effect of Optogenetics Varies With Distance From Channelrhodopsin-2 Expression in an Amyloid-β-Injected Mouse Model of Alzheimer’s Disease

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the most common cause of dementia. Optogenetics uses a combination of genetic engineering and light to activate or inhibit specific neurons in the brain.Objective: The objective of the study was to examine the ef...

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Bibliographic Details
Main Authors: Xiaorui Cui, Feng Zhang, Hui Zhang, Xi Huang, Kewei Wang, Ting Huang, Xifei Yang, Liangyu Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
amyloid-1-42
channelrhodopsin-2
memory
novel object recognition
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.583628/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.583628/full

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