Plasticity and Constraints of tRNA Aminoacylation Define Directed Evolution of Aminoacyl-tRNA Synthetases

Plasticity and Constraints of tRNA Aminoacylation Define Directed Evolution of Aminoacyl-tRNA Synthetases

Genetic incorporation of noncanonical amino acids (ncAAs) has become a powerful tool to enhance existing functions or introduce new ones into proteins through expanded chemistry. This technology relies on the process of nonsense suppression, which is made possible by directing aminoacyl-tRNA synthet...

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Bibliographic Details
Main Authors: Ana Crnković, Oscar Vargas-Rodriguez, Dieter Söll
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
aminoacyl-tRNA synthetases
noncanonical amino acids
directed evolution
genetic code expansion
synthetic biology
Online Access:https://www.mdpi.com/1422-0067/20/9/2294

Internet

https://www.mdpi.com/1422-0067/20/9/2294

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