KMUP-1 inhibits hypertension-induced left ventricular hypertrophy through regulation of nitric oxide synthases, ERK1/2, and calcineurin

KMUP-1 inhibits hypertension-induced left ventricular hypertrophy through regulation of nitric oxide synthases, ERK1/2, and calcineurin

Hypertension can induce left ventricular hypertrophy (LVH), and the nitric oxide (NO) pathway plays an important role in the pathogenesis of cardiac hypertrophy. This study aimed to examine whether KMUP-1, a novel xanthine-based derivative, could inhibit LVH in spontaneously hypertensive rats (SHRs)...

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Bibliographic Details
Main Authors: Jwu-Lai Yeh, Chung-Pin Liu, Jong-Hau Hsu, Ching-Jiunn Tseng, Ping-Ju Wu, Yi-Ya Wang, Jiunn-Ren Wu, Ing-Jun Chen
Format: Article
Language:English
Published: Wiley 2012-11-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
Calcineurin A
Cardiac hypertrophy
Extracellular signal-regulated kinase
Hypertension
Nitric oxide synthase
Online Access:http://www.sciencedirect.com/science/article/pii/S1607551X12001167

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http://www.sciencedirect.com/science/article/pii/S1607551X12001167

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