Harmful Iron-Calcium Relationship in Pantothenate kinase Associated Neurodegeneration

Harmful Iron-Calcium Relationship in Pantothenate kinase Associated Neurodegeneration

Pantothenate Kinase-associated Neurodegeneration (PKAN) belongs to a wide spectrum of diseases characterized by brain iron accumulation and extrapyramidal motor signs. PKAN is caused by mutations in PANK2, encoding the mitochondrial pantothenate kinase 2, which is the first enzyme of the biosynthesi...

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Bibliographic Details
Main Authors: Paolo Santambrogio, Maddalena Ripamonti, Chiara Paolizzi, Celeste Panteghini, Miryam Carecchio, Luisa Chiapparini, Marzia Raimondi, Alicia Rubio, Ivano Di Meo, Anna Cozzi, Stefano Taverna, Giuseppe De Palma, Valeria Tiranti, Sonia Levi
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
neurodegeneration
PKAN (pantothenate kinase-associated neurodegeneration)
NBIA (neurodegeneration with brain iron accumulation)
iron
calcium
iPSC (induced pluripotent stem cells)
Online Access:https://www.mdpi.com/1422-0067/21/10/3664

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https://www.mdpi.com/1422-0067/21/10/3664

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