Crohn's disease-associated ATG16L1 T300A genotype is associated with improved survival in gastric cancer

Crohn's disease-associated ATG16L1 T300A genotype is associated with improved survival in gastric cancer

Background: A non-synonymous single nucleotide polymorphism of the ATG16L1 gene, T300A, is a major Crohn's disease (CD) susceptibility allele, and is known to be associated with increased apoptosis induction in the small intestinal crypt base in CD subjects and mouse models. We hypothesized tha...

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Bibliographic Details
Main Authors: Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:EBioMedicine
Subjects:
Autophagy
Apoptosis
Genotyping
Transcriptomics
Stratification
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421001407

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http://www.sciencedirect.com/science/article/pii/S2352396421001407

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