Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The molecular basis of how Plasmodium falciparum sporozoites migrate through host cells is poorly understood, and direct evidence of its importance in vivo is lacking. Here, we generated traversal-deficient sporozo...

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Bibliographic Details
Main Authors: Annie S.P. Yang, Matthew T. O’Neill, Charlie Jennison, Sash Lopaticki, Cody C. Allison, Jennifer S. Armistead, Sara M. Erickson, Kelly L. Rogers, Andrew M. Ellisdon, James C. Whisstock, Rebecca E. Tweedell, Rhoel R. Dinglasan, Donna N. Douglas, Norman M. Kneteman, Justin A. Boddey
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
malaria
sporozoite
hepatocyte
virulence
motility
invasion
perforin
SPECT
transmission
genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303340

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http://www.sciencedirect.com/science/article/pii/S2211124717303340

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