Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening.

Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening.

There is significant need to identify novel prostate cancer drug targets because current hormone therapies eventually fail, leading to a drug-resistant and fatal disease termed castration-resistant prostate cancer. To functionally identify genes that, when silenced, decrease prostate cancer cell pro...

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Bibliographic Details
Main Authors: Kimberly Brown Dahlman, Joel S Parker, Tambudzai Shamu, Haley Hieronymus, Caren Chapinski, Brett Carver, Kenneth Chang, Gregory J Hannon, Charles L Sawyers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3324507?pdf=render

Internet

http://europepmc.org/articles/PMC3324507?pdf=render

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