Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

Acetyl-CoA is a key metabolic intermediate with an important role in transcriptional regulation. The nuclear-cytosolic acetyl-CoA synthetase 2 (ACSS2) was found to sustain the growth of hypoxic tumor cells. It generates acetyl-CoA from acetate, but exactly which pathways it supports is not fully und...

Full description

Bibliographic Details
Main Authors: Vinay Bulusu, Sergey Tumanov, Evdokia Michalopoulou, Niels J. van den Broek, Gillian MacKay, Colin Nixon, Sandeep Dhayade, Zachary T. Schug, Johan Vande Voorde, Karen Blyth, Eyal Gottlieb, Alexei Vazquez, Jurre J. Kamphorst
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
acetate
acetyl-CoA synthetase 2
cancer metabolism
enzyme localization
histone acetylation
histone deacetylation
hypoxia
lipogenesis
metabolite compartmentalization
stable isotope tracing
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317624

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716317624

Similar Items