Immune Tolerance to Apoptotic Self Is Mediated Primarily by Regulatory B1a Cells

Immune Tolerance to Apoptotic Self Is Mediated Primarily by Regulatory B1a Cells

The chronic autoimmune inflammatory diseases, systemic lupus erythematosus and Sjogren’s syndrome, develop when tolerance to apoptotic cells (ACs) is lost. We have previously reported that this tolerance is maintained by innate-like, IL-10 secreting regulatory B cells. Two questions remained. First,...

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Bibliographic Details
Main Authors: Katherine Miles, Joanne Simpson, Sheila Brown, Graeme Cowan, David Gray, Mohini Gray
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
regulatory
B cell
B1a
apoptotic cell
immune tolerance
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01952/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01952/full

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