Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization

Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization

Mitochondria are signaling hubs in cellular physiology that play a role in inflammatory diseases. We found that partial inhibition of the mitochondrial ATP synthase in the intestine of transgenic mice triggers an anti-inflammatory response through NFκB activation mediated by mitochondrial mtROS. Thi...

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Bibliographic Details
Main Authors: Laura Formentini, Fulvio Santacatterina, Cristina Núñez de Arenas, Konstantinos Stamatakis, David López-Martínez, Angela Logan, Manuel Fresno, Ron Smits, Michael P. Murphy, José M. Cuezva
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
ATP synthase
cytokines
innate immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305302

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http://www.sciencedirect.com/science/article/pii/S2211124717305302

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