Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization
Mitochondria are signaling hubs in cellular physiology that play a role in inflammatory diseases. We found that partial inhibition of the mitochondrial ATP synthase in the intestine of transgenic mice triggers an anti-inflammatory response through NFκB activation mediated by mitochondrial mtROS. Thi...
Main Authors: | Laura Formentini, Fulvio Santacatterina, Cristina Núñez de Arenas, Konstantinos Stamatakis, David López-Martínez, Angela Logan, Manuel Fresno, Ron Smits, Michael P. Murphy, José M. Cuezva |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-05-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717305302 |
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