Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.

Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.

The synthetic triterpenoid 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid (CDDO) and derivatives display anti-tumor activity against a variety of cultured tumor cell lines and in mouse xenografts. In this report, we have studied the effects of CDDO and its imidazolide derivative (CDDO-Im) on chronic...

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Bibliographic Details
Main Authors: Christina L Kress, Marina Konopleva, Vanesa Martínez-García, Maryla Krajewska, Sophie Lefebvre, Marc L Hyer, Teresa McQueen, Michael Andreeff, John C Reed, Juan M Zapata
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1891436?pdf=render

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http://europepmc.org/articles/PMC1891436?pdf=render

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