Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium

Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium

Summary: Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent HSCs are active. The relationship between “dormant” and “active” HSCs remains unresolved. Here we generate a G0 marker (G0M) mouse line that visualizes quiescent cells and identify a small population o...

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Bibliographic Details
Main Authors: Tsuyoshi Fukushima, Yosuke Tanaka, Fiona K. Hamey, Chih-Hsiang Chang, Toshihiko Oki, Shuhei Asada, Yasutaka Hayashi, Takeshi Fujino, Taishi Yonezawa, Reina Takeda, Kimihito Cojin Kawabata, Tomofusa Fukuyama, Terumasa Umemoto, Keiyo Takubo, Hitoshi Takizawa, Susumu Goyama, Yasushi Ishihama, Hiroaki Honda, Berthold Göttgens, Toshio Kitamura
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719315529

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http://www.sciencedirect.com/science/article/pii/S2211124719315529

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