Mangiferin Relieves Lipopolysaccharide-Induced Injury by Up-Regulating miR-181a via Targeting PTEN in ATDC5 Cells

Mangiferin Relieves Lipopolysaccharide-Induced Injury by Up-Regulating miR-181a via Targeting PTEN in ATDC5 Cells

BackgroundMangiferin (MF) was reported to possess anti-inflammatory activity. This investigation tried to probe into the underlying mechanism of MF in osteoarthritis.MethodsATDC5 cells were pretreated with series concentrations of MF (0.1, 1, 5, 10, 15, 20 μM) for 2 h and then were exposed to lipopo...

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Bibliographic Details
Main Authors: Yunfei Ma, Ying Liu, Yunyan Ma, Nan Jiang, Lei Wang, Bowei Wang, Wanting Niu, Yanjun Hu, Qingrong Lin, Bin Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritis
mangiferin
PTEN
miR-181a
NF-κB
PTEN/PI3K/AKT pathways
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00137/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00137/full

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