Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Background and Aims: Monocyte chemotactic protein-1 (MCP-1) is a potent chemoattractant for monocytes. It is involved in pathogenesis of several inflammatory diseases. Hepatic MCP-1 is a readout of macrophage activation. While inflammation is a major driver of liver disease progression, the origin a...

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Bibliographic Details
Main Authors: Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
acute-on-chronic liver failure (ACLF)
decompensated liver cirrhosis
inflammation
monocyte chemotactic protein 1 (MCP-1)
transjugular intrahepatic portosystemic shunt (TIPS)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00354/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00354/full

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