Granulosa cell endothelin-2 expression is fundamental for ovulatory follicle rupture

Abstract Ovulation is dependent upon numerous factors mediating follicular growth, vascularization, and ultimately oocyte release via follicle rupture. Endothelin-2 (EDN2) is a potent vasoconstrictor that is transiently produced prior to follicle rupture by granulosa cells of periovulatory follicles...

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Bibliographic Details
Main Authors: Joseph A. Cacioppo, Po-Ching Patrick Lin, Patrick R. Hannon, Daniel R. McDougle, Arnon Gal, CheMyong Ko
Format: Article
Language:English
Published: Nature Publishing Group 2017-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-00943-w