Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

Pathogens have evolved a range of mechanisms to counteract host defenses, notably to survive harsh acidic conditions in phagosomes. In the case of Mycobacterium tuberculosis, it has been shown that regulation of phagosome acidification could be achieved by interfering with the retention of the V-ATP...

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Bibliographic Details
Main Authors: Christophe J. Queval, Ok-Ryul Song, Jean-Philippe Carralot, Jean-Michel Saliou, Antonino Bongiovanni, Gaspard Deloison, Nathalie Deboosère, Samuel Jouny, Raffaella Iantomasi, Vincent Delorme, Anne-Sophie Debrie, Sei-Jin Park, Joana Costa Gouveia, Stanislas Tomavo, Roland Brosch, Akihiko Yoshimura, Edouard Yeramian, Priscille Brodin
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
Mycobacterium tuberculosis
macrophages
high-content imaging
phagosome acidification
CISH
H+ V-ATPase
ubiquitination
protosomal degradation
GM-CSF
STAT5
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312615

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http://www.sciencedirect.com/science/article/pii/S2211124717312615

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