Synthesis, Anticonvulsant, Sedative and Anxiolytic Activities of Novel Annulated Pyrrolo[1,4]benzodiazepines

Synthesis, Anticonvulsant, Sedative and Anxiolytic Activities of Novel Annulated Pyrrolo[1,4]benzodiazepines

Four new pentacyclic benzodiazepine derivatives (PBDTs 13–16) were synthesized by conventional thermal heating and microwave-assisted intramolecular cyclocondensation. Their anticonvulsant, sedative and anxiolytic activities were evaluated by drug-induced convulsion models, a pentobarbital-induced h...

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Bibliographic Details
Main Authors: Kumaraswamy Sorra, Chien-Shu Chen, Chi-Fen Chang, Srinivas Pusuluri, Khagga Mukkanti, Chi-Rei Wu, Ta-Hsien Chuang
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:International Journal of Molecular Sciences
Subjects:
benzodiazepine
thiadiazolone
pyrimidinone
cyclocondensation
anticonvulsant
sedative
anxiolytic
Online Access:http://www.mdpi.com/1422-0067/15/9/16500

Internet

http://www.mdpi.com/1422-0067/15/9/16500

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