Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.

USP14 is a cysteine protease deubiquitinase associated with the proteasome and plays important catalytic and allosteric roles in proteasomal degradation. USP14 inhibition has been considered a therapeutic strategy for accelerating degradation of aggregation-prone proteins in neurodegenerative diseas...

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Bibliographic Details
Main Authors: Jayashree Chadchankar, Victoria Korboukh, Leslie C Conway, Heike J Wobst, Chandler A Walker, Peter Doig, Steve J Jacobsen, Nicholas J Brandon, Stephen J Moss, Qi Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0225145

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https://doi.org/10.1371/journal.pone.0225145

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