Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice

Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice

Triglyceride (TG) accumulation in hepatocytes (hepatic steatosis) preludes the development of advanced nonalcoholic fatty liver diseases (NAFLDs) such as steatohepatitis, fibrosis, and cirrhosis. Mutations in human Comparative Gene Identification-58 (CGI-58) cause cytosolic TG-rich lipid droplets to...

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Bibliographic Details
Main Authors: Feng Guo, Yinyan Ma, Anil K.G. Kadegowda, Jenna L. Betters, Ping Xie, George Liu, Xiuli Liu, Hongming Miao, Juanjuan Ou, Xiong Su, Zhenlin Zheng, Bingzhong Xue, Hang Shi, Liqing Yu
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Journal of Lipid Research
Subjects:
triglyceride hydrolysis
lipase
fatty liver
CGI-58
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520375271

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http://www.sciencedirect.com/science/article/pii/S0022227520375271

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