Synthesis and Characterization of a Gd-DOTA--Permeation Peptide for Magnetic Resonance Relaxation Enhancement of Intracellular Targets

Many MR contrast agents have been developed and proven effective for extracellular nontargeted applications, but exploitation of intracellular MR contrast agents has been elusive due to the permeability barrier of the plasma membrane. Peptide transduction domains can circumvent this permeability bar...

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Bibliographic Details
Main Authors: Andrew M. Prantner, Vijay Sharma, Joel R. Garbow, David Piwnica-Worms
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2003-10-01
Series:Molecular Imaging
Online Access:https://doi.org/10.1162/15353500200303106