Bortezomib-Loaded Mesoporous Silica Nanoparticles Selectively Alter Metabolism and Induce Death in Multiple Myeloma Cells

Bortezomib-Loaded Mesoporous Silica Nanoparticles Selectively Alter Metabolism and Induce Death in Multiple Myeloma Cells

A mesoporous silica-based nanodevice bearing the antineoplastic drug bortezomib (BTZ), whose release is triggered in acidic environment and grafted with folic acid (FOL) as a targeting function (FOL-MSN-BTZ) was tested on folate receptor overexpressing (FR+) multiple myeloma (MM) cells and on FR neg...

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Bibliographic Details
Main Authors: Alessandra Nigro, Luca Frattaruolo, Mariarosa Fava, Ilaria De Napoli, Marianna Greco, Alessandra Comandè, Marzia De De Santo, Michele Pellegrino, Elena Ricci, Francesca Giordano, Ida Perrotta, Antonella Leggio, Luigi Pasqua, Diego Sisci, Anna Rita Cappello, Catia Morelli
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
mesoporous silica nanoparticles
target therapy
bortezomib
Multiple Myeloma
apoptosis
energy metabolism
Online Access:https://www.mdpi.com/2072-6694/12/9/2709

Internet

https://www.mdpi.com/2072-6694/12/9/2709

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