Deletion of Akt1 Promotes Kidney Fibrosis in a Murine Model of Unilateral Ureteral Obstruction

We investigated the role of Akt1, one of the three isoforms of Akt, in renal fibrosis using the murine model of unilateral ureteral obstruction (UUO). We subjected wild type and Akt1−/− mice to UUO. The Akt1 gene was silenced in vitro using short hairpin RNA delivered via a lentiviral vector in huma...

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Bibliographic Details
Main Authors: Il Young Kim, Min Young Lee, Mi Wha Park, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Sun Sik Bae, Sang Soo Kim, Sang Heon Song
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2020/6143542