Do we need to detect isoniazid resistance in addition to rifampicin resistance in diagnostic tests for tuberculosis?

Multidrug-resistant tuberculosis (MDR-TB) is resistant to both rifampicin (RIF) and isoniazid (INH). Whereas many TB diagnostics detect RIF-resistance, few detect INH-monoresistance, which is common and may increase risk of acquired MDR-TB. Whether inclusion of INH-resistance in a first-line rapid t...

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Bibliographic Details
Main Authors: Claudia M Denkinger, Madhukar Pai, David W Dowdy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3880287?pdf=render