The Interplay of Rogue and Clustered Ryanodine Receptors Regulates Ca2+ Waves in Cardiac Myocytes

Ca2+ waves in cardiac myocytes can lead to arrhythmias owing to delayed after-depolarisations. Based on Ca2+ regulation from the junctional sarcoplasmic reticulum (JSR), a mathematical model was developed to investigate the interplay of clustered and rogue RyRs on Ca2+ waves. The model successfully...

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Bibliographic Details
Main Authors: Xudong Chen, Yundi Feng, Yunlong Huo, Wenchang Tan
Format: Article
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
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