The Interplay of Rogue and Clustered Ryanodine Receptors Regulates Ca2+ Waves in Cardiac Myocytes
Ca2+ waves in cardiac myocytes can lead to arrhythmias owing to delayed after-depolarisations. Based on Ca2+ regulation from the junctional sarcoplasmic reticulum (JSR), a mathematical model was developed to investigate the interplay of clustered and rogue RyRs on Ca2+ waves. The model successfully...
Main Authors: | Xudong Chen, Yundi Feng, Yunlong Huo, Wenchang Tan |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-04-01
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Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2018.00393/full |
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