Deletion of genes involved in the ketogluconate metabolism, Entner-Doudoroff pathway, and glucose dehydrogenase increase local and invasive virulence phenotypes in Streptococcus pneumoniae.

Deletion of genes involved in the ketogluconate metabolism, Entner-Doudoroff pathway, and glucose dehydrogenase increase local and invasive virulence phenotypes in Streptococcus pneumoniae.

Streptococcus pneumoniae displays increased resistance to antibiotic therapy following biofilm formation. A genome-wide search revealed that SP 0320 and SP 0675 (respectively annotated as 5-keto-D-gluconate-5-reductase and glucose dehydrogenase) contain the highest degree of homology to CsgA of Myxo...

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Main Authors: Fen Z Hu, Jarosław E Król, Chen Hsuan Sherry Tsai, Rory A Eutsey, Luisa N Hiller, Bhaswati Sen, Azad Ahmed, Todd Hillman, Farrel J Buchinsky, Laura Nistico, Bethany Dice, Mark Longwell, Edward Horsey, Garth D Ehrlich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0209688

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https://doi.org/10.1371/journal.pone.0209688

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