Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R

Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R

Meprin β is a metalloprotease associated with neurodegeneration, inflammation, extracellular matrix homeostasis, transendothelial cell migration, and cancer. In this study, we investigated two melanoma-associated variants of meprin β, both exhibiting a single amino acid exchange, namely, meprin β G4...

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Bibliographic Details
Main Authors: Antonin Gellrich, Franka Scharfenberg, Florian Peters, Martin Sammel, Ole Helm, Fred Armbrust, Frederike Schmidt, Juliane Lokau, Christoph Garbers, Susanne Sebens, Philipp Arnold, Christoph Becker-Pauly
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
metalloprotease
meprin
sheddase
IL-6
CD99
APP
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.702341/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.702341/full

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