In vivo plug-and-play: a modular multi-enzyme single-cell catalyst for the asymmetric amination of ketoacids and ketones

In vivo plug-and-play: a modular multi-enzyme single-cell catalyst for the asymmetric amination of ketoacids and ketones

Abstract Background Transaminases have become a key tool in biocatalysis to introduce the amine functionality into a range of molecules like prochiral α-ketoacids and ketones. However, due to the necessity of shifting the equilibrium towards the product side (depending on the amine donor) an efficie...

Full description

Bibliographic Details
Main Authors: Judith E. Farnberger, Elisabeth Lorenz, Nina Richter, Volker F. Wendisch, Wolfgang Kroutil
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Microbial Cell Factories
Subjects:
Biocatalysis
Single-cell biotransformation
Escherichia coli
Asymmetric reductive amination
Transaminases
Chiral amines
Online Access:http://link.springer.com/article/10.1186/s12934-017-0750-5

Internet

http://link.springer.com/article/10.1186/s12934-017-0750-5

Similar Items