Absence of the Non-Signalling Chemerin Receptor CCRL2 Exacerbates Acute Inflammatory Responses In Vivo

Absence of the Non-Signalling Chemerin Receptor CCRL2 Exacerbates Acute Inflammatory Responses In Vivo

Chemerin is a chemotactic protein that induces migration of several immune cells including macrophages, immature dendritic cells, and NK cells. Chemerin binds to three G protein-coupled receptors (GPCRs), including CCRL2. The exact function of CCRL2 remains unclear. CCRL2 expression is rapidly upreg...

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Bibliographic Details
Main Authors: Daniel Regan-Komito, Sophia Valaris, Theodore S. Kapellos, Carlota Recio, Lewis Taylor, David R. Greaves, Asif J. Iqbal
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
CCRL2
chemerin
G protein-coupled receptor
inflammation
chemokines
neutrophils
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01621/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01621/full

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