Enriching Human Interactome with Functional Mutations to Detect High-Impact Network Modules Underlying Complex Diseases

Enriching Human Interactome with Functional Mutations to Detect High-Impact Network Modules Underlying Complex Diseases

Rapid progress in high-throughput -omics technologies moves us one step closer to the datacalypse in life sciences. In spite of the already generated volumes of data, our knowledge of the molecular mechanisms underlying complex genetic diseases remains limited. Increasing evidence shows that biologi...

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Bibliographic Details
Main Authors: Hongzhu Cui, Suhas Srinivasan, Dmitry Korkin
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Genes
Subjects:
protein–protein interaction network
module detection
gwas
network propagation
functional annotation
complex diseases
Online Access:https://www.mdpi.com/2073-4425/10/11/933

Internet

https://www.mdpi.com/2073-4425/10/11/933

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